落继先，女，硕士生导师，研究方向，细胞信号转导

教育背景
2007.9-2010.7 东北师范大学 生命科学学院 遗传与细胞研究所 博士
2005.9-2007.7 东北师范大学 生命科学学院 遗传与细胞研究所 硕士
2000.9-2004.7 长春师范学院 生命科学学院 学士

研究背景
2014.1-至今   山西大学 生命科学学院  副教授
2012.11-2014.3  德州大学医学分部（University of Texas Medical Branch），访问学者2010.7-2013.12 山西大学 生命科学学院  讲师

主持及参与科研项目
[1] RhoGDI2的磷酸化在SDF-1引起的β1整合素介导的Jurkat细胞迁移过程中的作用研究，国家自然科学青年基金(31401216)，2015.1.1-2017.12.31，25万，主持。
[2] 镉影响华溪蟹蜕皮过程的分子机制，国家基金委博士后基金面上基金(2012M510773) 2012.5.22-2014.11.21，5万，主持。
[3] RhoGDI2在PSGL-1信号通路中的作用及机制研究，教育部新教师基金(20121401120006)，2013.1.1-2015.12.31，4万，主持。
[4] 重组华溪蟹金属硫蛋白在AUMO融合系统中的表达及其功能研究（高等学校博士学科点专项科研基金博导类(20111401110010)，2012.1.1-2014.12.31，6万，参与，排名第三
[5] PI3K激酶在L-选择素和PSGL-1介导的白细胞起始黏附过程中的信号转导作用研究，国家自然科学基金面上基金(30971498)，2010.1.1-2012.12.31，35万，参与，排名第三。

发表SCI论文
[1] Jixian Luo, Koa Hosoki, Attila Bacsi, Zsolt Radak, Muralidhar L. Hegde, Sanjiv Sur, Tapas K. Hazra, Allan R. Brasier, Xueqing Ba, Istvan Boldogh*. 8-Oxoguanine DNA glycosylase-1-mediated DNA repair is associated with Rho GTPase activation and α-smooth muscle actin polymerization. Free Radical Biology & Medicine. 73:430-8. 2014.（二区，IF=5.710）
[2] Jixian Luo, Sihui Pei, Weixin Jing, Enmin Zou, Lan Wang*. Cadmium inhibits molting of the freshwater crab Sinopotamon henanense by reducing the hemolymph ecdysteroid content and the activities of chitinase and N-acetyl-β-glucosaminidase in the epidermis. Comparative biochemistry and physiology. Part C. 169:1-6. 2014.（三区 IF= 2.829）
[3] Jixian Luo, Tingshuang Xu, Chunfeng Li, Xueqing Ba, Xiaoguang Wang*, Yong Jiang, Xianlu Zeng*. p85-RhoGDI2, a novel complex, is required for PSGL-1-induced β1 integrin-mediated lymphocyte adhesion to VCAM-1. The International Journal of Biochemistry & Cell Biology. 45(12): 2764-2773. 2013. （二区，IF=4.24）
[4] Jixian Luo, Chunfeng Li, Tingshuang Xu, Wenai Liu, Xueqing Ba, Xiaoguang Wang*, Xianlu Zeng*.  PI3K is involved in β1 integrin clustering by PSGL-1 and promotes β1 integrin-mediated Jurkat cell adhesion to fibronectin. Molecular and Cellular Biochemistry. 385(1-2): 287-295. 2013. (四区 IF=2.388)
[5] Jixian Luo, Tingshuang Xu, Xiaoguang Wang, Xue Feng, Xueqing Ba, Xianlu Zeng. PI3K is involved in L-selectin- and PSGL-1-mediated neutrophil rolling on E-selectin via F-actin redistribution and assembly. Journal of Cellular. Biochemistry. 110 (4): 910-919. 2010.
[6] Yongquan Li, Huizhen Yang, Na Liu, Jixian Luo, Qian Wang, Lan Wang*. Cadmium accumulation and metallothionein biosynthesis in cadmium-treated freshwater mussel Anodonta woodiana. PLoS One. 10(2):e0117037. 2015.
[7] Xueqing Ba, Attila Bacsi, Jixian Luo, Leopoldo Aguilera-Aguirre, Xianlu Zeng, Zsolt Radak, Allan R. Brasier, Istvan Boldogh*.8-oxoguanine DNA glycosylase-1 augments proinflammatory gene expression by facilitating the recruitment of site-specific transcription factors. Journal of Immunology. 192(5):2384-94. 2014.
[8] Tingshuang Xu, Wenai Liu, Jixian Luo, Chunfeng Li, Xueqing Ba, Khamal Kwesi Ampah, Xiaoguang Wang, Yong Jiang, Xianlu Zeng*. Lipid Raft is required for PSGL-1 ligation induced HL-60 cell adhesion on ICAM-1. PLoS One. 8(12):e81807. 2013.
[9] Wenwen Lei, Lan Wang*, Dongmei Liu, Tuan Xu, Jixian Luo. Histopathological and biochemical alternations of the heart induced by acute cadmium exposure in the freshwater crab Sinopotamon yangtsekiense. Chemosphere. 84(5):689-94.2011.
[10] Lingling Cui, Cuixia Chen, Ting Xu, Juechao Zhang, Xin Shang, Jixian Luo, Liang Chen, Xueqing Ba, Xianlu Zeng*. c-Abl Kinase is required for β-2 integrin-medated neutrophil adhesion. Journal of Immunology. 182 (5): 3233-3242. 2009.
[11] Ting Xu, Liang Chen, Xin Shang, Lingling Cui, Jixian Luo, Cuixia Chen, Xueqing Ba and Xianlu Zeng*. Critical role of Lck in L-selectin signaling induced by sulfatides engagement. Journal of Leukocyte Biology. 84 (8): 1192-1201. 2008.
[12] Cuixia Chen, Xin Shang, Lingling Cui, Ting Xu, Jixian Luo, Xueqing Ba, Xianlu Zeng*. L-selectin ligation-induced CSF-1 genetranscription is regulated by AP-1 in a c-Abl kinase-dependent manner. Human Immunology. 69 (8): 501-509. 2008.
[13] Cuixia Chen, Xin Shang, Ting Xu, Lingling Cui, Jixian Luo, Xueqing Ba, Shui Hao and Xianlu Zeng*. c-Abl is required for the signaling transduction induced by L-selectin ligation. European Journal of Immunology. 37 (11): 3246-3258. 2007.

联系方式
电 话(Tel)：0351-7018796
E-mail：luojx@sxu.edu.cn; laojixian@aliyun.com
地 址(Add)：山西省太原市坞城路92号，山西大学生命科学学院
邮 编(Pc)：030006