张瑞凯，男，山西永济人，校聘副教授

教育经历

2019.09-2023.07 天津科技大学 食品科学与工程 工学博士

2015.09-2018.07 山西大学 细胞生物学 理学硕士

2011.09-2015.07 太原工业学院 生物工程 工学学士

工作经历

2024.03-至今 山西大学生命科学学院 校聘副教授

研究方向

1. 纤毛病及致病机理研究。

2. 分子生物学工具和合成生物学策略在莱茵衣藻为底盘生物的应用研究。

招生专业

水生生物学（学术型硕士）

发表论文

1. Rui-Kai Zhang^#, Wei-Yue Sun^#, Yan-Xia Liu, Emma Y. Zhang and Zhen-Chuan Fan*. RABL2 Promotes the Outward Transition Zone Passage of Signaling Proteins in Cilia via ARL3. Proc Natl Acad Sci USA, 2023, 120(34): e2302603120. (IF=11.1, SCI 一区 top)

2. Rui-Kai Zhang, Pu Wang, Yu-Cheng Lu, Lang Lang, Lan Wang, Shao Chin Lee*.  Cadmium induces cell centrosome amplification via reactive oxygen species as well as endoplasmic reticulum stress pathway. J Cell Physiol, 2019, 234(10): 18230-18248. (IF=5.6, SCI 二区)

3. Yan-Xia Liu^#, Rui-Kai Zhang^#, Zhen-Chuan Fan^*. RABL4/IFT27 in a nucleotide-independent manner promotes phospholipase D ciliary retrieval via facilitating BBSome reassembly at the ciliary tip. J Cell Physiol, 2023, 238(3): 549-565. (共同一作, IF=5.6, SCI 二区)

4. Chan Zhang^#, Rui-Kai Zhang^#, Ying Feng^#, Sheng-Nan Sun, Zhen-Chuan Fan^*. Green algae-derived triple CATH_BRALE multimer protein potently inhibits bacterial growth by permeabilizing the bacterial cell membrane. Process Biochem, 2023, 130: 555-565. (共同一作, IF=4.4, SCI 三区)

5. Wei-Yue Sun^#, Bin Xue^#, Yan-Xia Liu^#, Rui-Kai Zhang , Rong-Chao Li, Wen Xin, Ming fu Wu,   Zhen-Chuan Fan*. Chlamydomonas LZTFL1 mediates phototaxis via controlling BBSome recruitment to the basal body and its reassembly at the ciliary tip. Proc Natl Acad Sci USA, 2021, 118(35): e2101590118. (IF=11.1, SCI 一区 top)

6. Yan-Xia Liu^#, Wen-Juan Li^#, Rui-Kai Zhang, Sheng-Nan Sun, Zhen-Chuan Fan*. Unraveling the intricate Cargo-BBSome Coupling Mechanism at the Ciliary Tip. Proc Natl Acad Sci USA, 2023, 120(13): e2218819120. (IF=11.1, SCI一区top)

7. Yan-Xia Liu; Wei-Yue Sun; Bin Xue; Rui-Kai Zhang; Wen-Juan Li; Xi-xian Xie; Zhen-Chuan Fan^*; ARL3 mediates BBSome ciliary turnover by promoting its outward movement across the transition zone. J Cell Biol, 2022, 221(10): e202111076. (IF=7.8, SCI 一区)

8. Yu-Cheng Lu; Pu Wang; Qi-Gui Wu; Rui-Kai Zhang; Alice Kong; Yuan-Fei Li; Shao Chin Lee^*;  Hsp74/14- 3-3σ complex mediates centrosome amplification by High Glucose, Insulin, and Palmitic Acid. Proteomics, 2019, 19(7): e1800197. (IF=3.4, SCI 三区)

9. 张瑞凯；张艳花；刘琴琴；杨华丽；李少钦^*；重金属镉通过DNA氧化损伤途径诱导细胞中心体扩增, 生物技术通讯， 29(02): 60-65.

10. 张婵；张瑞凯；刘雁霞；樊振川^*；小G蛋白ARL3多克隆抗体制备及其突变体鉴定，食品与生物技术学报，(已接收).

联系方式

E-mail: zhangruikai@sxu.edu.cn

地址：山西省太原市南中环东街63号，山西大学生命科学学院