李晨，女，理学博士，副教授，硕士生导师。
研究方向：蛋白质与酶工程
招生专业：食品科学（学术型硕士）、生物与医药（专业型硕士）。
教育及科研经历：
2017/08–2018/09，加拿大麦吉尔大学，食品化学，访问学者
2010/09–2014/06，山西大学，生物化学与分子生物学，博士
2003/09–2006/06，山西大学，生物化学与分子生物学，硕士
1999/09–2003/06，太原师范学院，化学，学士
工作经历：
2016/11–今，山西大学，生命科学学院，副教授
2009/10-2016/10，山西大学，生命科学学院，讲师
主持及参与科研项目：
1. 国家自然科学基金青年基金（主持）： 荞麦Potato I型抑制剂延缓秀丽隐杆线虫衰老的机制研究。
2. 山西省自然科学基金（主持）：磁性纳米胰蛋白酶亲和吸附剂的构建及应用研究。
3. 山西省高校科技创新项目（主持）： BTI控释芯鞘纳米纤维支架的构建及生物学评价。
4. 山西省回国留学人员科研资助项目（主持）：BTI的分子改造及一种新型胰蛋白酶亲和材料的制备。
5. 山西省自然科学基金（主持）：核壳结构槲皮素纳米微粒的制备及其性能研究。
6. 太原市科技创新项目（主持）：植物多糖的制备及其生物活性研究。
7. 杏花村学院开放基金（主持）：一种酒糟活性肽保健酒的研制及功能评价。
8. 企业合作项目（主持）：核桃青皮提取物成分的分离鉴定。
9. 国家自然科学基金面上项目（参与）：食品过敏原TBa, TBb抗原决定簇的定位及免疫功能研究。
10. 国家自然科学基金青年科学基金项目（参与）：荞麦 Potato I 型蛋白酶抑制剂诱导 Hep G2 细胞线粒体自噬的分子机制。
11. 山西省自然科学基金（参与）：BTI靶向TOM20诱导线粒体自噬的分子机制及延缓衰老效应。
12. 山西省科技攻关计划项目（参与）：新型抗肿瘤靶向药物重组胰蛋白酶抑制剂的研发。
近五年发表论文:
1. Chen Li, Yunwei Wang, Zijia Huang, Yi Zhang, Jiao Li, Qing Zhang, Benjamin Simpson, Jingxue Wang*. Hypoglycemic effect of polysaccharides of Dendrobium officinale compound on type 2 diabetic mice. Journal of Functional Foods, 2023, Accepted.
2. Xiaodong Cui*, Wenhua Tian, Wenhua Wang, Jiao Li, Zhuanhua Wang, Chen Li*. Sequence analysis and biochemical characteristics of two non-specific lipid transfer proteins from Tartary buckwheat seeds. Protein and Peptide Letters, 2023, Accepted.
3. Chen Li, Xin Liu, Anzhi Li, Fang Li*. Effect of recombinant buckwheat trypsin inhibitor on gel properties of chicken meat emulsion. International Journal of Food Science and Technology, 2022, 58(2):802-810.
4. Jiao Li*, Min Sun, Xiaodong Cui, Chen Li*. Protective effects of flavonoids against Alzheimer’s Disease: pathological hypothesis, potential targets, and structure-activity relationship. International Journal of Molecular Sciences, 2022, 23, 10020.
5. Chen Li, Qiannan Hu, Yaqi Liang, Yuxiang Wei, Jingxue Wang*. Physicochemical properties and application in film preparation of prolamin from distiller’s grains. International Journal of Food Science and Technology, 2022, 57, 5206-5215.
6. Chen Li, Yuhang Han, Liufang Gao, Yi Zhang, Benjamin Kofi Simpson. Development of a novel trypsin affinity material using a recombinant buckwheat trypsin inhibitor mutant with enhanced activity. LWT-Food Science and Technology, 2021, 146:111382.
7. Chen Li, Yuhang Han, Sanhong Fan, Lizhen Ma, Yi Zhang, Benjamin Kofi Simpson. Effect of three kinds of natural preservative cocktails on vacuum-packed chilled pork. Food Science ＆Nutrition, 2020, 8:3110-3118.
8. Chen Li*, Wenjie Li, Yi Zhang, Benjamin Kofi Simpson*. Comparison of physicochemical properties of recombinant buckwheat trypsin inhibitor (rBTI) and soybean trypsin inhibitor (SBTI). Protein Expression and Purification, 2020, 171:105614.
9. Chen Li, Lina Ning, Xiaodong Cui, Xiao Li Ma, Jiao Li, Zhuanhua Wang. Recombinant buckwheat trypsin inhibitor decreases fat accumulation via the IIS pathway in Caenorhabditis elegans. Experimental Gerontology, 2019, 128:110753.
10. Chen Li, Liufang Gao, Yi Zhang, Benjamin Kofi Simpson. Preparation of quercetin loaded microparticles and their antitumor activity against human lung cancer cells (A549) in vitro. Current Pharmaceutical Biotechnology, 2019, 20(11): 945-954.
11. Yurong Sun, Xiaoping Li, Sanhong Fan*, Chen Li*, Zengfu Shang, Mengmeng Gu, Shufeng Liang, Xin Tian*. The in vitro and in vivo toxicity of black phosphorus nanosheets. Journal of Nanoscience and Nanotechnology, 2019, 19:1-8.
12. Chen Li, Yurong Sun, Xiaoping Li, Sanhong Fan*, Yimin Liu, Xiumei Jiang, Mary D. Boudreau, Yue Pan*, Xin Tian*, JunJie Yin. Bactericidal effects and accelerated wound healing using Tb4O7 nanoparticles with intrinsic oxidaselike activity. J Nanobiotechnol, 2019, 17: e54.
13. Chen Li, Xiaoping Li, Chengzhi Bai, Yi Zhang, Zhuanhua Wang. A chitinase with antifungal activity from naked oat (Avena chinensis) seeds. J. Food Biochem., 2018，e12713.
14. Patrick Blondin Tsafack, Chen Li, Apollinaire Tsopmo*. Food peptides, gut microbiota modulation, and antihypertensive effects. Molecules, 2022, 27, 8806.
15. Guoyang Feng, Xiaojun Fan*, Yanna Liang, Chen Li, Junde Xing and Yongji He. Genomic and Transcriptional Characteristics of Strain Rum-meliibacillus sp. TYF-LIM-RU47 with an Aptitude of Directly Producing Acetoin from Lignocellulose. Fermentation, 2022, 8, 414
16. Yi Zhang, Chen Li, Timothy Geary, Armando Jardim, Shudong He, Benjamin K. Simpson*. Cold setting of gelatin–antioxidant peptides composite hydrogels using a new psychrophilic recombinant transglutaminase (rTGase). Food Hydrocolloids, 2022, 122:107116.
17. Yi Zhang, Chen Li, Timothy Geary, Benjamin Kofi Simpson. Contribution of special structural features to high thermal stability of a cold-active transglutaminase. Journal of Agricultural and Food Chemistry, 2020, 68: 7935-7945.
18. Xiaodong Cui*, Bairui Zhang, Zhe Li, Chen Li, Jiao Li*. Zhuyeqing liquor promotes longevity through enhancing stress resistance via regulation of SKN-1 and HSF-1 transcription factors in Caenorhabditis elegans. Experimental Gerontology, 2023,174: 112131
19. Xiaodong Cui, Ke Wang, Tingfen Wang, Jiao Li, Chen Li, Wenming Wang, Hongfei Wang, Zhuanhua Wang. Crystal Structure Analysis of Cationic Peroxidase from Proso Millet and Identification of Its Phosphatase Active Sites, J. Agric. Food Chem, 2021, 69: 6251-6259.
20. Xiaodong Cui*, Yifan Lv, Zhuanhua Wang, Jiao Li, Chen Li. Regulating inhibitory activity of potato I-type proteinase inhibitor from buckwheat by rutin and quercetin. Journal of Food Biochemistry, 2021, 00: e13780.
21. Xiaoli Ma, Jiao Li, Xiaodong Cui, Chen Li, Zhuanhua Wang. Dietary supplementation with peptides from sesame cake alleviates Parkinson’s associated pathologies in Caenorhabditis elegans. Journal of Functional Foods. 2020, 65: 103737.
22. Jiao Li, Cuixiao Dong, Ma Xiaoli, Li Chen, Zhuanhua Wang*. Recombinant Buckwheat Trypsin Inhibitor Improves the Protein and Mitochondria Homeostasis in Caenorhabditis elegans Model of Aging and Age-Related Disease. Gerontology, 2019, 65 (5):513-523
23. Yi Zhang, Pierre Dutilleul, Chen Li, Benjamin K. Simpson. Alcalase-assisted production of fish skin gelatin rich in high molecular weight (HMW) polypeptide chains and their characterization for film forming capacity, LWT-Food Sci Tech, 2019,110:117-125.
24. Qing Wang, Deng-Guang Yu*, Sun-Yi Zhou, Chen Li and Min Zhao*. Electrospun amorphous medicated nanocomposites fabricated using a Teflon-based concentric spinneret. E-polymer, 2018, 18(1): 3-11.
25. Chen Li. Recombinant expression of a novel chymotrypsin from Loligo opalescent in Escherichia coli. 8th Annual Bioconnect Symposium in Montreal. 2018，19:35.
26. 李娇, 梁雅琪, 李晨*. 白酒糟醇溶蛋白的磷酸化改性及功能性质. 食品工业科技, 2023, 44(9): 60-67.
27. 李晨, 牛泽洁, 李文婕, 韩宇航, 王景雪*,. BTI和Nisin复合涂膜液对鲈鱼鱼糜的保鲜效果. 食品研究与开发. 2021, 42(22):8-13.
28. 胡倩楠, 韩宇航，李晨*. rBTI对鲈鱼鱼糜凝胶特性的影响. 食品研究与开发，2020, 41(21): 22-28.
29. 高柳芳, 李晨*. 一种胰蛋白酶亲和材料的制备及应用. 食品工业, 2020, 4:172-176.
30. 李霞, 栗安之, 李晨*. 响应面法优化荞麦胰蛋白酶抑制剂固定化条件. 生物技术通讯, 2019, 30: 28-34.
31. 李晨, 宁丽娜, 崔晓东, 李娇，王转花*. 苦荞凝集素的稳定性及体外消化性. 食品工业科技, 2018, 39(24):57-61.
国家发明专利：
1. 李晨, 崔晓东, 李娇. 一种重组型荞麦胰蛋白酶抑制剂突变体以及胰蛋白酶亲和材料，专利号： ZL201910217184.X。
2. 范三红, 李晨, 王亚云. 一种超声波协同复合酶法从菊芋中提取高纯度菊糖的方法， 专利号：ZL201310413180.1。
获奖：
1. 2018年度山西省“三晋英才”支持计划青年优秀人才。
2. 2021年获山西省教授协会授予的“山西省高校教学名师”称号。
教学工作:
承担本科生课程“生物化学”“食品化学”“生物化学实验”。
联系方式:
E-mail: lichen@sxu.edu.cn
Tel: 13834043529
地 址：山西省太原市南中环东街63号，山西大学东山校区生命科学学院
邮 编：030031