李娇，女，1989年生，山西长治人，中共党员，山西大学生命科学学院讲师，硕士生导师。

Email: lijiao@sxu.edu.cn

教育经历：

2012.09-2017.07 山西大学生命科学学院，生物化学与分子生物学专业，博士。

2008.09-2012.07 山西大学生命科学学院，生物科学专业，学士。

工作经历：

2017.7-至今，山西大学生命科学学院，讲师。

教学工作：

承担本科生课程“食品生物化学”“生物化学实验”等。

研究方向：

生物活性物质的提取、纯化及功能研究，尤其是衰老及衰老相关疾病干预生物活性物质的研究。

发表论文：

1. 李娇，崔晓东，李玉英，冯思思，王转花*. rBTI的制备及其对果蝇寿命的影响， 食品科学，2014, 35: 7，202-205

2. Li Jiao， Cui Xiaodong, Wang Zhuanhua*, Li Yuying. rBTI extends Caenorhabditis elegans lifespan by mimicking calorie restriction. Experimental Gerontology . 2015,67: 62-71.

3. 李娇，崔晓东，马晓丽，王转花*. rBTI及其突变体对 C. elegans 寿命的影响, 生物化学与分子生物学学报, 2016, 32: 10, 1112-1120.

4. Li Jiao, Cui Xiaodong, Xiaoli Ma, Wang Zhuanhua*. rBTI reduced β-amyloid-induced toxicity by promoting autophagy-lysosomal degradation via DAF-16 in Caenorhabditis elegans. Experimental Gerontology . 2017,89: 78-86.

5. Li Jiao, Cui Xiaodong, Xiaoli Ma, Chen Li, Wang Zhuanhua*. Recombinant Buckwheat Trypsin Inhibitor Improves the Protein and Mitochondria Homeostasis in Caenorhabditis elegans Model of Aging and Age-Related Disease. Gerontology. 2019, 21:1-11.

6. Jiao Li , Min Sun, Xiaodong Cui and Chen Li*. Protective Effects of Flavonoids against Alzheimer’s Disease: Pathological Hypothesis, Potential Targets, and Structure–Activity Relationship. International Journal of Molecular Sciences. 2022, 23(17):10020.

7. Jiao Li, Jiani Wang, Ziqian Huang, Xiaodong Cui, Chen Li*. Oxidized quercetin has stronger anti-amyloid activity and anti-aging effect than native form. Comparative Biochemistry and Physiology, Part C. 2023, 271:109676.

8. Jiao Li, Wenyan Li, Jianjian Hu, Chen Li, Xiaodong Cui*. Proso millet peroxidase-mediated degradation and detoxification of Rhodamine B in water. Environmental Technology. 2023,11:1-11.

9. Xiaoli Ma, Jiao Li, Yi Zhang, Orcun Hacariz, Jianguo Xia, Benjamin K. Simpson  and Zhuanhua Wang*. Oxidative stress suppression in C. elegans by peptides from dogfish skin via regulation of transcription factors DAF-16 and HSF-1. Food & Function. 2022,13(2):716-724.（共同第一作者）

10. 李娇，梁雅琪，王景雪，李 晨*. 白酒糟醇溶蛋白的磷酸化改性及功能性质, 食品工业科技，2023，44（9：60−67.

11. Xiaodong Cui, Bairui Zhang, Zhe Li, Chen Li, Jiao Li*. Zhuyeqing liquor promotes longevity through enhancing stress resistance via regulation of SKN-1 and HSF-1 transcription factors in Caenorhabditis elegans. Experimental Gerontology. 2023, 174: 112131.

12. Chen Li, Lina Ning, Xiaodong Cui, Xiaoli Ma, Jiao Li^⁎, Zhuanhua Wang^⁎. Recombinant buckwheat trypsin inhibitor decreases fat accumulation via the IIS pathway in Caenorhabditis elegans. Experimental Gerontology . 2019,128(110753).

13. Zhuanhua Wang, Xiaoli Ma, Jiao Li, Xiaodong Cui. Peptides from sesame cake extend healthspan of Caenorhabditis elegans via upregulation of skn-1 and inhibition of intracellular ROS levels. Experimental Gerontology. 2016,82: 139-149.

14. Zhuanhua Wang, Shanshan Li, Rong Ren, Jiao Li, and Xiaodong Cui. Recombinant Buckwheat Trypsin Inhibitor Induces Mitophagy by Directly Targeting Mitochondria and Causes Mitochondrial Dysfunction in Hep G2 Cells. J. Agric. Food Chemistry, 2015, 9 2015. 63(35):7795-7804.

15. Xiaoli Ma, Xiaodong Cui, Jiao Li, Zhuanhua Wang*. Peptides from sesame cake reduce oxidative stress and amyloid-β-induced toxicity by upregulation of SKN-1 in a transgenic Caenorhabditis elegans model of Alzheimer’s disease. Journal of Functional Foods, 2017,39:287-298.

16. Xiaoli Ma, Jiao Li, Xiaodong Cui, Zhuanhua Wang*. Dietary supplementation with peptides from sesame cake protect Caenorhabditis elegans from polyglutamine-induced toxicity. Journal of Functional Foods. 2019,54:199-210.

17. Fang Li, Xiaoli Ma, Xiaodong Cui, Jiao Li, Zhuanhua Wang^⁎. Recombinant buckwheat glutaredoxin intake increases lifespan and stress resistance via hsf-1 upregulation in Caenorhabditis elegans. Experimental Gerontology . 2018,104: 86-97.

18. Xiaodong Cui, Jingjing Du, Jiao Li, Zhuanhua Wang*. Inhibitory site of α-hairpin in peptide from tartary buckwheat has no effect on its antimicrobial activities. Acta Biochim Biophys Sin, 2018, 1–9.

19. 李芳，崔晓东，马晓丽，李娇，王转花*. 谷氧还蛋白rbGrx可延缓CL4176 秀丽隐杆线虫中β淀粉样蛋白诱导的毒性, 生物化学与分子生物学学报 , 2016, 34: 10, 844-853.

20. 李晨，宁丽娜，崔晓东，李娇，王转花*. 苦荞凝集素的稳定性及体外消化性. 食品工业科技, 生物化学与分子生物学学报, 2016, 39: 24, 57-61.

主持及参与项目：

1. 山西省应用基础项目（面上项目）：“BTI靶向TOM20诱导线粒体自噬的分子机制

及延缓衰老效应” 项目编码202203021211302 （主持）

2. 山西省应用基础项目：“荞麦PotatoⅠ型蛋白酶抑制剂降低C. elegans脂肪积累机制研究” 项目编码201801D221244（主持）

3. 山西省高校科技创新项目: “基于槲皮素诱导自噬的效应的探究其减缓Aβ细胞毒性的机制”，项目编号：2019L0055（主持）

4. 杏花村学院开放基金：“清香型白酒糟总黄酮的制备及其在露酒中的应用”，项目编号：XCSDU-KF-202219（主持）

5. 企业合作项目：“大便潜血（FOB）检测试剂盒研发”（主持）

6. 国家自然科学基金项目：“荞麦Patoto Ⅰ型蛋白酶抑制剂延缓秀丽隐杆线虫衰老的机制研究”，项目编号：31600631（主要参与人）

7. 国家自然科学基金项目：“荞麦Patoto Ⅰ型蛋白酶抑制剂诱导Hep G2细胞线粒体自噬的分子机制”，项目编号31300653（主要参与人）

8. 山西省应用基础项目：“基于Potato I型蛋白酶抑制剂序列靶向线粒体多肽的分子改造及抗肿瘤效应研究” 项目编码201801D121192（主要参与人）

9. 高校科技创新项目：“抗肿瘤蛋白酶抑制剂rBTI的增效改造” 项目编码201802020（主要参与人）